Some Comon and Usual adverse effects of Non-steroidal anti-inflammatory drugs (NSAID) drugs

An estimated 10–20% of people taking NSAIDs experience indigestion. In the 1990s high doses of prescription NSAIDs were associated with serious upper gastrointestinal adverse events, including bleeding. NSAIDs, like all medications, may interact with other medications. For example, concurrent use of NSAIDs and quinolone antibiotics may increase the risk of quinolones adverse central nervous system effects, including seizure.

May 17, 2022 - 16:31
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The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly common.

The use of NSAIDs increases the risk of a range of gastrointestinal (GI) problems, kidney disease and adverse cardiovascular events. As commonly used for post-operative pain, there is evidence of an increased risk of kidney complications.

Their use following gastrointestinal surgery remains controversial, given mixed evidence of increased risk of leakage from any bowel anastomosis created. An estimated 10–20% of people taking NSAIDs experience indigestion. In the 1990s high doses of prescription NSAIDs were associated with serious upper gastrointestinal adverse events, including bleeding. NSAIDs, like all medications, may interact with other medications.

For example, concurrent use of NSAIDs and quinolone antibiotics may increase the risk of quinolones adverse central nervous system effects, including seizures.

There is an argument over the benefits and risks of NSAIDs for treating chronic musculoskeletal pain. Each drug has a benefit-risk profile and balancing the risk of no treatment with the potential competing risks of various therapies should be considered.

For people over the age of 65 years old, the balance between the benefits of pain-relief medications such as NSAIDs and the potential for adverse effects has not been well determined.

There is some evidence suggesting that, for some people, the use of NSAIDS (or other anti-inflammatories) may contribute to the initiation of chronic pain.

In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.

They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.

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