Cardiovascular and Possible erectile dysfunction risk of using NSAIDs - Pain Killers ?

use of NSAIDs (aside from low-dose aspirin) was associated with a more than 10-fold increase in heart failure. If this link is proven causal, researchers estimate that NSAIDs would be responsible for up to 20 per cent of hospital admissions for congestive heart failure. In people with heart failure, NSAIDs increase mortality risk (hazard ratio) by approximately 1.2–1.3 for naproxen and ibuprofen..

May 17, 2022 - 16:37
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Cardiovascular

NSAIDs, aside from aspirin, increase the risk of myocardial infarction and stroke. This occurs at least within a week of use.

They are not recommended in those who have had a previous heart attack as they increase the risk of death or recurrent MI.

Evidence indicates that naproxen may be the least harmful out of these. NSAIDs aside from (low-dose) aspirin are associated with a doubled risk of heart failure in people without a history of cardiac disease.

In people with such a history, use of NSAIDs (aside from low-dose aspirin) was associated with a more than 10-fold increase in heart failure.

If this link is proven causal, researchers estimate that NSAIDs would be responsible for up to 20 percent of hospital admissions for congestive heart failure.

In people with heart failure, NSAIDs increase mortality risk (hazard ratio) by approximately 1.2–1.3 for naproxen and ibuprofen, 1.7 for rofecoxib and celecoxib, and 2.1 for diclofenac.

On 9 July 2015, the Food and Drug Administration (FDA) toughened warnings of increased heart attack and stroke risk associated with nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin.

Possible erectile dysfunction risk:

A 2005 Finnish survey study found an association between long term (over 3 months) use of NSAIDs and erectile dysfunction.

A 2011 publication in The Journal of Urology received widespread publicity. According to the study, men who used NSAIDs regularly were at significantly increased risk of erectile dysfunction.

A link between NSAID use and erectile dysfunction still existed after controlling for several conditions. However, the study was observational and not controlled, with a low original participation rate, potential participation bias, and other uncontrolled factors.

The authors warned against drawing any conclusion regarding the cause.

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